The answer is both yes and no. As this serum contains hyaluronic acid, along with trace minerals and other components, it serves as an initial boost to your moisturizing routine, making the use of a dedicated moisturizer optional. However, it is advisable to use a moisturizer. One of the unique abilities of this product is to enhance the effectiveness of subsequent treatments. Therefore, layering on a moisturizer that contains additional key or active ingredients will provide extra benefits.